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Scientists Create Vaccine Blocking Fentanyl From Entering the Brain

Scientists Create Vaccine Blocking Fentanyl From Entering the Brain

More good news: Drug overdose deaths may finally be plateauing across nation for first time since start of Covid pandemic.

A team of researchers at the University of Houston announced a vaccine that could block fentanyl from entering the brain and stops users from getting high. The vaccine is being hailed as a “game changer” in the battle against the opioid overdose epidemic.

In testing on rats, the vaccine “produced significant amounts” of anti-fentanyl antibodies that clung to the deadly addictive synthetic opioid, according to a study printed in the journal Pharmaceutics.

That prevented the drug “from entering the brain, allowing it to be eliminated out of the body via the kidneys,” said lead author Colin Haile of the University of Houston’s Drug Discovery Institute.

“Thus, the individual will not feel the euphoric effects and can ‘get back on the wagon’ to sobriety,” said Haile, predicting it “could have a significant impact on a very serious problem plaguing society for years.”

The drug is described as a vaccine, as it will create antibodies to target fentanyl and prevent it from entering the brain.

The vaccine works by stimulating T-cells in the immune system to create antibodies which bind to fentanyl in the bloodstream.

These immune proteins catch the drug as it enters the body and prevent it from spreading further and causing harm. It then gets processed in the kidney and flushed from the body.

Researchers told DailyMail.com the vaccine could be used by people suffering from opioid use disorder or college students who experiment with illicit substances.

While not great news, there is a hopeful sign that opioid deaths are also declining in this country.

Preliminary data shows there were 107,600 fatalities estimated in the year to June 2022, the latest available, some 40 fewer than the tally in the 2021 calendar year.

Officials heralded the early figures as ‘hopeful’ and praised the wider availability of naloxene, a drug that treats overdoses from opioids — America’s biggest killer.
…However, some experts said the drop was simply due to deaths returning to pre-pandemic levels. Overdoses spiked to record highs during Covid.

Overdose deaths have been rising in the US since 1990s amid a flood of illicit substances crossing the border from Mexico.

They surged to a record 108,000 in the year to February, after the Covid pandemic, which was blamed on the economic turmoil and social isolation caused by lockdowns and other restrictions.

Hopefully, the new vaccine will help speed up that trend.

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UnCivilServant | November 18, 2022 at 11:02 am

The mRNA fiasco has made me hesitant to trust ‘vaccines’ produced in current day.


     
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    healthguyfsu in reply to UnCivilServant. | November 18, 2022 at 11:13 am

    Well I assume you’re not an addict so there’d be no reason for you to get one.


       
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      Voyager in reply to healthguyfsu. | November 18, 2022 at 11:46 am

      Not necessarily. If it provides long lasting protection from the stuff, it may be worth dosing anyway to prevent addiction or death from unintentional consumption. The stuff keeps turning up in weird places, and it doesn’t take much more than a skittle sized tablet to put you in the ground.

      Consider, if they manage a vaccine against roofies, would you consider it, even if you did not plan on taking them? I would expect it to be worth considering.

      That said, yes, the way drug companies have incinerated their integrity the last few years does make me skeptical of this, especially if people start pushing for broad mandates and immunity from prosecution.


         
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        healthguyfsu in reply to Voyager. | November 18, 2022 at 11:56 am

        Fentanyl is still routinely used in hospital settings because it produces an optimal anesthesia when dosed properly and monitored. Why would you want or need a vaccine against it? Why would a mandate be pushed for this? It would be bipartisan unpopular. The last mandate was able to be forced because it divided the country ideologically. This one, not so much.

        Plus, I’d be willing to bet this vaccine will not be authorized for “just in case” use.


         
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        Otto Kringelein in reply to Voyager. | November 18, 2022 at 12:35 pm

        No thanks, I’ll leave this anti-fentanyl serum to the rats and wait for the reports to come out when they actually test it on human beings. And don’t forget, just because it works in rats doesn’t mean it’ll have the same affect in humans.


         
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        Dathurtz in reply to Voyager. | November 18, 2022 at 12:38 pm

        Fentanyl has legitimate medical uses and you want those to work.


         
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        MattMusson in reply to Voyager. | November 18, 2022 at 12:54 pm

        Plenty of First Responders have overdosed trying to help unconscious addicts.


     
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    gonzotx in reply to UnCivilServant. | November 18, 2022 at 4:13 pm

    Is it perchance a mRNA technology ?


       
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      Otto Kringelein in reply to gonzotx. | November 19, 2022 at 12:38 pm

      Most likely as that’s the new fad in vaccine technology that the pharmaceutical companies are pushing onto the people despite the complete debacle their previous mRNA serum was after they trialed it on millions (billions?) of innocent people.


 
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SeiteiSouther | November 18, 2022 at 11:11 am

If this actually works, it’s an amazing good sign.


     
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    healthguyfsu in reply to SeiteiSouther. | November 18, 2022 at 11:18 am

    My enthusiasm is tempered. How many addicts will actually want this? Sounds like torture to an addict who craves this high.

    I guess this becomes another societal question about its use. Should it be voluntary? Should it even be legal?

    What happens if an addict tries to shoot up anyways? Might they go into anaphylaxis with enough dose and attempts? What about cross reactivity with chemical similars? A vaccine targeting a non-infectious exogenous substance raises several warning flags about unintended consequences such as autoimmune disease.


     
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    UnCivilServant in reply to SeiteiSouther. | November 18, 2022 at 11:20 am

    I already have questions – what effect does it have on other opiods? On other painkillers? On unrelated chemicals? What side effects does it have? How long does the immune response persist? What effect does massive amounts of Fentanyl have on other organs if a person suffering withdrawl pumps a lot of it into their system looking for some effect?

    I know, nobody knows right now. I just wonder.


       
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      Morning Sunshine in reply to UnCivilServant. | November 18, 2022 at 12:24 pm

      wondering is good. Ask the questions. That is the problem with the covidiots – they did not allow questions that would have resolved concerns. Probably because the answers were not useful to the narrative


       
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      smalltownoklahoman in reply to UnCivilServant. | November 18, 2022 at 12:38 pm

      They link to a story from the NYPost and at the bottom of the article we have this tidbit: “They also “expect minimal side effects in clinical trials” because the main components are already widely used and tested.

      Also, the antibodies proved specific to fentanyl, meaning “a vaccinated person would still be able to be treated for pain relief with other opioids,” Haile noted. ”

      So if that’s accurate and proves true in human clinical trials that means it shouldn’t effect other opiods.


     
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    Paula in reply to SeiteiSouther. | November 18, 2022 at 11:29 am

    Maybe they can come up with a vaccine to make everybody the same color.


 
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Dolce Far Niente | November 18, 2022 at 11:16 am

Its pointless, in the end.

If people are so anxious to change their brain chemistry with substances that are clearly deadly, then making one toxic high unavailable will only lead to druggies using an alternate.

Its the users that have to change, not the drug or its effects.


 
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healthguyfsu | November 18, 2022 at 11:23 am

There’s a typo in the quoted report (sic?)

The drug to treat OD is naloxone not “naloxene”, which doesn’t exist. It is commonly referred to by it’s brand name form, which is Narcan.

An easier way is to bock it from going in your mouth.

This is insanely stupid.

First, Fentanyl is used every day in surgery and intensive care units for its pain-relieving properties. Without knowing that a patient has had this vaccine – and it’s absolutely certain that there will be many cases where we can’t possibly know – we will block pain relief and sedation in patients who are unable to tell us they’re hurting. The antibodies don’t discriminate between a “high” and sedation to keep you from ripping out your breathing tube. If it works we will have to change practice radically and eliminate the agent pretty much entirely.

Second, it’s specfic to fentanyl, so addicts using heroin, oxycodone, oxymorphone, or dozens of other legal and illegal drugs will simply have to revert to their drug of choice. If it cross-covers carfentanil, a close derivative, that agent (a hundred times as potent as fentanyl) won’t be used extensively, but it almost certainly doesn’t cover the nitazenes, which are just as potent (and dangerous) as carfentanil. Blocking one agent alone is pointless.

Third, this is a preliminary press release related to experiments in rats. This is years from responsible deployment (let’s not have another mRNA fiasco, please) and there’s so much that can go wrong in this kind of testing that it’s absolutely guaranteed this will do nothing to alleviate the current overdose epidemic. It’s just feel-good won’t-it-be-wonderful pablum.

    Third, fentanyl is dirt cheap and effective in miniscule doses. If this miracle ‘vaccine’ is administered to addicts as a legal ‘The verdict is Probation but only if you are vaccinated against the drug that got you arrested’ deal, what stops the addict from taking ten or a hundred times the previous dose so he can get high despite this? Would that put the minimum effective dose higher than the minimum lethal dose and kill even more addicts?

“announced a vaccine that could block fentanyl from entering the brain and stops users from getting high”

Only one design flaw – getting the user to take the vaccine.

So let’s tally up: China has tried biowarfare (Covid) and chemical warfare (fentanyl).

What’s left? (rhetorical)


     
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    Paula in reply to Dimsdale. | November 18, 2022 at 5:20 pm

    What’s next? The sky’s the limit.

    According to the people in upstate New York, we have won the war on global warming. Now we can now turn our attention to China see what we have to fear next.


     
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    venril in reply to Dimsdale. | November 19, 2022 at 8:31 pm

    Year ago, a co-worker had been an A&P mechanic for Saudia, in Jeddah. He recounted a day on the line when they witnessed a drug smuggler being dragged off an airplane on the tarmac, marched behind a hanger and shot on the spot.

    The answer to this crap? Catch smugglers at the border with a backpack full of heroin or fentayl? Shoot him on the spot and leave him on the other side of the border. It’ll slow quickly enough.


 
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nordic prince | November 18, 2022 at 12:08 pm

Another “vaccine” – what could possibly go wrong?


     
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    henrybowman in reply to nordic prince. | November 18, 2022 at 3:36 pm

    I know fer a fact that I’m going to run right out and get it, and have them give it to all my kids, my dogs, and my farm animals. Because saaaaaaaaaafety! Early Adopter is my middle name (given me by my maw, whose middle name was But All My Friends Are Jumping Off The Bridge).


     
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    Paula in reply to nordic prince. | November 18, 2022 at 5:27 pm

    No need for another vaccine. The people in Pennsylvania have invented a new strain of kool aid. All you have to do is take one sip and it will block common sense from entering the brain and users will get high on Fetterman.


 
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ThePrimordialOrderedPair | November 18, 2022 at 12:10 pm

They have really abused the word “vaccine” into utter meaninglessness, at this point. For leftists, that is the greatest accomplishment.


 
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CommoChief | November 18, 2022 at 12:33 pm

I really don’t see the utility of this without a mandate, which would be highly intrusive. Even if it was ready for prime time and it is not then who is the target demo? We gonna round up addicts and force a jab? Gonna add it to the list for K-12 admission? College admission? Employers and other institutions, like colleges, who offer health insurance would have an incentive to nudge this if not mandate it. The insurance companies themselves would have that incentive as well. The federal govt reimburses, to a degree, ER and Ambulance service for indigent care so they have an incentive as well. Ditto for the DoD.


     
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    Dathurtz in reply to CommoChief. | November 18, 2022 at 12:44 pm

    I bet the point isn’t to produce a useful and deployable product, but rather to pay for the salaries and research of the researchers. If it safely works, it’s really neat. I don’t see how it will be societally useful, but it would be a neat bit of development.


       
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      CommoChief in reply to Dathurtz. | November 18, 2022 at 1:38 pm

      Yep all that is true re research and development stage. Then the numbers get run by the bean counters who figure out that making folks get this will save the insurance companies and the federal government a few bucks. Then there will be bipartisan agreement that this is a panacea and absolutely required.

      The whole protect will be billed as a way to protect the children and why wouldn’t we what that? Plus it will be touted as fiscally responsible. So unless you want the drug cartels to win you will get onboard, individual liberty be damned.

    Agreed, without some kind of mandate (i.e. forcing people to take this “vaccine”), it’s pretty useless. But they’ll mandate it for drug addicts / the homeless, and we’ll all just nod and say, yeah, that makes sense for “those people.” And the damage is done, if it’s okay to mandate a so-called vax for one group, it’s going to be okay to mandate whatever medical intervention they dream up for other groups . . . or for all of us. I don’t like slippery slopes, and this one looks particularly slimy.


     
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    henrybowman in reply to CommoChief. | November 18, 2022 at 3:46 pm

    I don’t see the target market as addicts. I see it as NPCs who have been panicked by all the unceasing reportage about how the size of a pinhead can kill you and it’s likely to be lurking in your kids’ halloween candy. And now here’s a “solution.” I’ll take a dozen!

    How many straights do you know who would take a vaccine against AIDS, or even m-word-pox, “just because?” I can name a handful, and those are just in my own extended family.


       
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      CommoChief in reply to henrybowman. | November 18, 2022 at 11:51 pm

      That and the pharmaceutical companies having gotten a taste of the profits from Rona Mandates want to continue that business model. The politicians they keep on speed dial will be more than happy to help.

Repurposing the Immune system has original antigenic sin or similar written all over it. Wait a decade or more for novel therapies (e.g. “vaccines”), evaluate the risk, and proceed accordingly.


     
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    henrybowman in reply to n.n. | November 18, 2022 at 3:52 pm

    And knowing that the freaks on the WEF envision all human bodies the same way “Pimp My Ride” hosts envision their participants’ jalopies, I’m not ready to put myself into any situation that requires somebody to start running weekly Windows Updates on my personal meat.


 
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chrisboltssr | November 18, 2022 at 1:04 pm

You know, there is a free “vaccine” against excessive fentanyl use. It’s called stop excessively using fentanyl.


 
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Ironclaw | November 18, 2022 at 1:51 pm

After the last few years, I’m not even remotely interested in anything those crooks call a “vaccine.”


 
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jhkrischel | November 18, 2022 at 2:16 pm

So, we’re developing tools to make people immune to pain killers.

At what point does this become a tool of torture, to prevent any pain relief compounds from being used?


 
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MajorWood | November 19, 2022 at 2:23 am

So the antibodies will recognize a specific region of the fentanyl molecule. The $64K question is what other endogenous/exogenous molecules have a similar region where cross reactivity could be an issue. The authors state that this isn’t an issue with a number of exogenous mu receptor agents, but what about the enkefalins, endorphin,and and endomorphin. I am sure that everyone will sign up for a treatment that makes them immune to pleasure in any form.

As a scientist, I can tell you that any breakthrough which oversells itself is simply a ploy for mo money. In terms of solving addiction, this does nothing. Addiction is a behavioral state of mind, and the substance is but a symptom. Just the most recent version of snake oil, IMHO


     
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    venril in reply to MajorWood. | November 19, 2022 at 11:21 pm

    Worse still, if the body cannot self medicate as it usually does, I wonder what sort of pain we’d have to endure all the time? Has there ever been a case of a person with failed natural production of these? Isn’t that part of cold turkey? The brain no long produces these since it’s overwhelmed by heroin?

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